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ManifoldMacro / FedUpdated 4m ago

Will any Millenium Problem in Biology be solved by EoY 2027?

Market probability
43.8%
1.4 percentage points
over 24 hours45.2%43.8%
467 days until the event deadline
Deadline: December 31, 2027 at 6:59 PM ET

A repricing with partial backing — read the new probability with some caution.

The pricing has partial support: moderate trading volume.

How credible was the move?

Three separate questions — a move can be genuine while the latest price is still settling. Methodology →

Move validity

Is the move backed by real trading and depth?

Moderate

The pricing has partial support: moderate trading volume.

Consensus stability

Has the market settled at the new probability?

Forming

Movement has slowed (2.8 points over six hours) but the market has not fully settled.

Contract clarity

Will the rules resolve without ambiguity?

High

The resolution rules are relatively specific, with a named source and a defined deadline.

Recent trade activity$250 traded

From the latest trade tape (most recent 200 prints) — a live activity sample, not a lifetime total.

What could move this market next?

  • The market's deadline arrivesDecember 31, 2027 at 6:59 PM ET

    The contract must resolve based on what has happened by this date.

Derived from the contract's own mechanics as of Sep 20, 5:42 AM ET. ProbCast does not list scheduled meetings, announcements, or data releases it cannot verify.

Advanced analysis (experimental)

Research signals — these models are still accumulating the history needed for full validation, and they can disagree with the headline read. Model confidence: low · expected error ±27 pts.

Thin marketLegacy movement classifier: watch

What's happening

medium classifier confidence
Thin market

Thin book and/or wide spread. Small orders can move this price disproportionately, so any single print is noisy and easily overread.

  • Thin book and/or wide spread.

Read with caution —Read the latest price with caution; conditions make it an unreliable summary right now.

More details — reliability score, dynamics, durability
Reliability score
0Low
Where the price path tends to go next663 observed
  • Illiquid / quiet99%

Short-term motion of the price line (~1h), distinct from the environment above — not a prediction of the final outcome.

DurabilityHigh· half-life ~3h
PredictabilityElevated irreducibility

Secondary read: leaning toward Resolving soon.

A read-only classification of the market environment — how much weight the current price deserves as a read of consensus. It describes conditions, never a trade.

Market data

24h volume

Ṁ250

Liquidity

Ṁ1K

Total volume

Ṁ250

Category
Macro / Fed
Venue
Manifold
Open interest
Current probability
43.8%
7-day range
41.0% – 45.2%
Resolves
Dec 31, 2027
Change (pts)1H0.06H+2.824H-1.47D-1.4

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